2 00 8 A waiting time problem arising from the study of multi - stage carcinogenesis
نویسنده
چکیده
We consider the population genetics problem: How long does it take before some member of the population has m specified mutations? The case m = 2 is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger m are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.
منابع مشابه
7 A waiting time problem arising from the study of multi - stage carcinogenesis
We consider the population genetics problem: How long does it take before some member of the population has m specified mutations? The case m = 2 is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger m are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.
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تاریخ انتشار 2009